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Conference: Health-care Associated Infections

December 11-12, 2008 QEII Conference Centre, London, UK
Join The Lancet Infectious Diseases to hear world-leading experts review the latest research and debate the most effective steps for reducing the burden of HAIs in clinical settings. To register, go to The Lancet Conference on HAI

Competition: Young Voices in Research for Health

The Lancet, together with the Geneva-based Global Forum for Health Research, announces the winners of the 2008 essay competition. Read the six winning essays at The Lancet Global Health Network.

Feature

Age-related macular degeneration

Eye Test - Copyright: Photo Library Age-related macular degeneration (AMD) is the main cause of blindness in 30·5 million people worldwide. According to a Comment, this devastating outcome might change in the near future because of remarkable research developments currently taking place, such as the finding in an Article that alterations in the SERPING1 gene are strongly associated with AMD. A Seminar gives a comprehensive overview of the disease, discussed in a podcast.
Selected Online First articles from The Lancet journals ahead of print publication.
The Anopheles mosquito that carries malaria - Copyright: Science Photo Library
Malaria protection for under-fives
Insecticide-treated bednets help to save lives of children in malaria-endemic countries. A study examines distribution of malaria risk and intervention coverage.
Article The Lancet (online Nov 18)
Skin cancer cell - Copyright: Science Photo Library
Surgical interventions for basal-cell carcinoma
There is a paucity of randomised trials assessing surgery for basal-cell carcinoma. Recurrence rates were compared after use of surgical excision or micrographic surgery.
Article The Lancet Oncology (online Nov 17)
HIV Vaccine - Copyright: Science Photo Library
HIV vaccine
Efficacy of the Merck HIV vaccine to prevent infection or reduce early viral burden through the induction of T-cell immunity alone was examined in a randomised trial.
Article The Lancet (online Nov 13)
  • Tissue-engineered airway transplantation
    Article The Lancet (online Nov 19) Full text|PDF
  • Inequalities in healthy life years in Europe
    Article The Lancet (online Nov 17) Full text|PDF
  • Beta blockers and non-cardiac surgery
    Article The Lancet (online Nov 11) Full text|PDF
  • Extensively drug-resistant tuberculosis
    Review The Lancet Infectious Diseases (online Nov 5) Full text|PDF
  • Endocrine therapy and recurrence of breast cancer
    Article The Lancet Oncology (online Oct 30) Full text|PDF
  • Sleep apnoea
    Seminar The Lancet (online Oct 30) PDF
The Lancet's summary of news and developments across medicine

President-elect Barack Obama signaled what is being viewed as a strong commitment to health-care reform by choosing former Senate Majority Leader Tom Daschle to head the federal department of Health and Human Services.

Clinical guidelines

The American College of Cardiology and American Heart Association have released the first guidelines for the treatment of adults with congenital heart disease. These guidelines are intended to support the care of the rising number of adults with repaired heart defects, by providing comprehensive clinical information on several heart defects and highlighting key issues to look for in follow-up.

Medical supplies

Aid agencies in the Democratic Republic of Congo say malnutrition and communicable diseases are taking their toll on refugees as fighting between government and rebel forces continues. A massive effort is under way to ensure the supply of life-saving medicines to hundreds of thousands of people, but, according to WHO, the biggest challenge is identifying where, and for which health conditions, supplies are needed most.

Malaria on trial

Malaria still kills around 1 million people every year, many of them young children in sub-Saharan Africa. A safe and effective vaccine is urgently needed to control the disease. A large make-or-break clinical trial of the RTS,S candidate vaccine, involving around 16 000 children, is soon to be launched in seven African countries.

More This Week in Medicine:

Most cited in The Lancet since 1996
1. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
Research (1998) Lancet 352 (9131), pp. 837-853
2. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: A randomised placebo-controlled trial
Research (2002) Lancet 360 (9326), pp. 7-22
3. Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: Principal results of the Hypertension Optimal Treatment (HOT) randomised trial
Research (1998) Lancet 351 (9118), pp. 1755-1762
4. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE)
Research (1996) Lancet 348 (9038), pp. 1329-1339
5. Peginterferon alfa-2b plus ribavirin compared with interferonalfa-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial
Research (2001) Lancet 358 (9286), pp. 958-965
Most read in The Lancet journals in October 2008
1. Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial
Research (2008) Lancet 372 (9645), pp. 1223-1230
2. Thrombolysis with alteplase 3-4·5 h after acute ischaemic stroke (SITS-ISTR): an observational study
Research (2008) Lancet 372 (9646), pp. 1303-1309
3. China and global health
Comment (2008) Lancet 372 (9648), pp. 1439-1441
4. Effect of candesartan on progression and regression of retinopathy in type 2 diabetes (DIRECT-Protect 2): a randomised placebo-controlled trial
Research (2008) Lancet 372 (9647), pp. 1385-1393
5. Childhood outcomes after prescription of antibiotics to pregnant women with preterm rupture of the membranes: 7-year follow-up of the ORACLE I trial
Research (2008) Lancet 372 (9646), pp. 1310-1318
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