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Newsflash |
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Should I give up medicine? |
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Have you every given consideration to this question? If so, you are certainly not alone - in fact almost every doctor or medical student has had doubts at some point in their career. |
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Archives of Disease in Childhood - Education and Practice current issue
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Highlights from this issue
Welcome to the February Epistle, and to an edition of Education and Practice which looks – and perhaps feels – a little different, but which contains most of the sections you are familiar with. Here is a summary of the changes. First, those of you reading this on paper will have noticed the new cover; this is traditional with a change in Editor in Chief and because we publish on even months you would have also seen the redesign on the blue journal and F&N first. Next, those of you reading on paper or as downloaded pdfs, we have changed the way the articles are laid out on the page. We think this looks better on the page, and hope that the papers feel a bit better when you read them. Ideally of course, you will not notice anything. Finally, one of the bugbears of a journal is the...
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Developmental assessment in the over 5s
The paediatrician's role in the developmental assessment of children under the age of 5 is well established, and so he/she might also have a role in the assessment of school-age children, particularly as (i) it is increasingly recognised that subtle presentations of developmental disorders may escape professional notice until school age, (ii) these disorders are interweaving and overlapping, necessitating a truly holistic view and (iii) no another professional group is equipped to deliver a single diagnostic assessment encompassing cognitive, communication, social, emotional and physical domains. However, assessment in the over-5s requires a different set of skills to the under-5s. The emphasis in this age group shifts from assessing developmental impairment, for example, a specific delay in walking or talking or a low developmental quotient, to assessing factors affecting the child's social or academic function. The paediatrician's task is to apply their knowledge of risks and vulnerabilities, using their experience in general and developmental paediatrics, paediatric neurology and child and adolescent mental health to identify environmental and/or biological factors affecting the child. The diagnostic focus that is a strength of paediatric practice needs to be tempered by a more flexible approach taking account of the child's strengths and difficulties. Finally, the clinician needs to decide if further assessment and investigations are required and make recommendations to help improve the outcome for the child. In this paper, the author will set out the context for these assessments, and then guide the reader through a clinical approach that the author has found useful.
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Disordered pubertal development
IntroductionPuberty is the physiological sequence of events when secondary sexual characteristics develop and reproductive capacity is achieved. The start of puberty is characterised by the appearance of a palpable breast bud (stage B2) in girls and testicular volumes of >3.5 ml in boys. These changes are brought about in response to the pulsatile secretion of gonadotropin releasing hormone (GnRH) from the hypothalamus stimulating the release of follicle stimulating hormone (FSH) and luteinising hormone (LH) from the anterior pituitary. It is still unclear why the GnRH neurons are usually inhibited after infancy until the start of puberty, although fat mass (via leptin signalling) and kisspeptin secreting neurons stimulating the GnRH system certainly play a role. LH acts on the gonads to increase the secretion of oestrogen in the female or nocturnal testosterone in the male that then promote growth in target tissues. FSH acts on the gonads to...
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It is all in the history, or is it?
‘Presentation—3 years old’Alice is referred by her general practitioner (GP) for a paediatric neurology opinion with a history of episodes of her legs giving way. The referral letter from her GP mentions that when Alice is picked up when she has one of these episodes, she cannot control her legs, which move abnormally. Alice is seen by the registrar. Her parents' say that these episodes are occurring at a frequency of one every month, and they describe non-rhythmic jerky movements involving her legs lasting approximately 20 min. She falls and cannot walk or stand when these happen. Recovery occurs without intervention. She has experienced a total of five episodes, and they all occurred in the evening following exertion. Her consciousness is not impaired during these events, and between the episodes Alice is well. The prenatal and perinatal history are normal, and her development is in keeping with...
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What I've learned from BMJ Case Reports: It's not just arthritis...
While reviewing over on BMJ Case Reports, I have come across some very curious paediatric articles and some that are not even catalogued under the paediatric specialty section but related to our practice. They can be found in the archive under the clinical and non-clinical sections. There is an abundance of weird and wonderful information on the website that serves to demonstrate unusual and unique learning points but also in some instances reiterate simpler things that we can sometimes take for granted in our busy working lives. My area of interest within paediatrics is rheumatology, so to start this series here are a couple of things from adult case reports that I thought I’d share with you here. Photosensitivity is an important counselling issue in children with systemic lupus erythematosus.1 This was demonstrated by the case of an adult who had unprotected exposure to sunlight, which...
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Options for procedural pain in newborn infants
Neonatologists often feel helpless in the management of procedural pain. While we acknowledge that our patients are more frequently and chronically exposed to tissue damaging procedures than any other hospital population, and that they are more vulnerable both in the short and long term, it is not certain that we have any techniques that are proven to be effective. Although we have developed numerous guidelines12 they are not reliably applied in clinical practice.3 It is widely recognised that newborns undergoing intensive care are necessarily subjected to numerous painful procedures.4 Despite the availability of clinical guidelines the majority of painful procedures on neonatal intensive care units (NICUs) are still carried out without any form of analgesia. Even outside the NICU term neonates are subjected to multiple procedures such as blood tests and insertion of nasogastric tubes. Surgical procedures such as circumcision,...
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How to use serum-specific IgE measurements in diagnosing and monitoring food allergy
BackgroundHypersensitivity (adverse reaction) to a food can be broadly divided into allergic hypersensitivity (food allergy) and non-allergic hypersensitivity (food intolerance).1 Food allergy is defined as an adverse immune response to a food allergen, whereas food intolerance is generally non-immune mediated. Food allergy can be subdivided into two main categories: IgE-mediated and non–IgE-mediated food allergy. The differences between the two are shown in table 1. Food intolerance incorporates several other adverse reactions to foods. These include toxic contaminants in food (eg, histamine in scombroid fish poisoning), pharmacological properties (eg, tyramine in aged cheese or caffeine), host characteristics (eg, lactase deficiency) and food aversion. Food allergies are common in the paediatric population, with up to 8% of young children affected by IgE-mediated reactions.2–4 Furthermore, up to a third of parents report their child having a food-related problem within the...
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What I've learned from Clinical Evidence: Head scratchers
Browsing in Clinical Evidence, I noticed six updated reviews and stumbled upon a couple of head scratchers for me. One of them, literally made my head itch. Bronchiolitis review. The holy grail has not been found. I thought we had a moderately good treatment in hypertonic saline when I read a systematic review that included four randomised controlled trials (RCT) and showed that 3% saline reduced mean length of stay by a day, and also improved clinical scores, when compared to 0.9% saline. But this review notes two subsequent RCTs that are not very encouraging. The first RCT included 46 children and there was no difference in hospital admission, oxygen saturation or clinical scores between 3% saline plus epinephrine and 0.9% saline plus epinephrine. The second RCT was larger, included 186 children, and also did not show any significant difference when using hypertonic saline. Since I know of...
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Babies born through meconium stained liquor with 5 min Apgar scores of 9 or 10 had very low risk of respiratory distress
Study designDesignProspective cohort of babies born through meconium stained amniotic fluid (MSAF) between 2003 and 2006. SettingTwo teaching hospitals in The Hague, The Netherlands. Patients394 term (>37/40) neonates were born through MSAF. The mean gestational age was 40 weeks, 56% were male, and mean birth weight was 3.5 kg. OutcomesMeconium aspiration syndrome (MAS) (respiratory distress, oxygen or mechanical ventilation requirement in the first 24 h of birth). Risk factors assessed included abnormalities of fetal heart trace, consistency of meconium, umbilical artery pH and 5 min Apgar score. Follow-up periodEvery baby was followed up for a minimum of 24 h before discharge if well. Main resultsOf 394 neonates, 19 (4.8%) developed respiratory distress compatible with MAS. Of the factors assessed, an Apgar score of 9 or 10 at 5 min had...
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Children diagnosed with otitis media by an otoscopist benefited from antibiotics but suffered more side effects
Study designDesignRandomised placebo-controlled trial. AllocationAllocation sequence computer-generated random number list. BlindingPhysicians, parents/caregivers. Study questionSettingSouthwest Finland, community based. Patients319 children aged 6–35 months diagnosed with acute otitis media by a qualified otoscopist. Intervention161 infants assigned to amoxicillin–clavulanate 40 mg/kg/dose (clavulanate 5.7 mg/kg) for 7 days. 158 assigned to placebo. OutcomesPrimary outcome was treatment failure (no overall improvement, no improvement in otoscopic signs, perforation, severe infection requiring antibiotics, adverse reaction); secondary outcomes included time to initiation of open label antibiotics and the development of contralateral otitis media. Follow-up periodUntil end of treatment visit on day 8. Patient follow-up161/162 in treatment versus 158/160 in placebo (compliance achieved in 94%). Main resultsIntention-to-treat analysis. The difference between the two groups was...
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